Clozapine monotherapy and ketoacidosis

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منابع مشابه

Diabetic ketoacidosis and clozapine.

1 Ring J, Messmer K. Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1977;1:466-9. 2 Laxenaire MC, Charpentier C, Feldman L. [Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicentre prospective study] (French). Ann FrAnesth Reanim 1994;13:301-10. 3 Watkins J, Wild G, Appleyard TN, Hardy G. Complemen...

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Clozapine Combined with Paliperidone Observations in Schizophrenic Patients with Insufficient Responses to Clozapine Monotherapy

Treatment resistance to clozapine often leads to antipsychotic combinations. Well-designed trials evaluated the add-on of several atypical antipsychotics, but the augmentation with paliperidone, the active metabolite of risperidone, has never been evaluated. Treatment of four cases resulted in a decrease of the PANSS-positive subscale, the mean initial clozapine dose could be lowered, mean prol...

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Clozapine and Neuroleptic Malignant Syndrome: Case Report and Risk Analysis of Monotherapy vs. Combination Therapy

Traditionally, patients who are considered treatment-resistant, or who present with more severe symptoms, are often considered for clozapine therapy. The combination of clozapine with another SGA, or on FGA, is also commonly utilized for such severe cases, and may be considered standard-of-care given the prevalence of these strategies. The following case report involves a chronically symptomati...

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Stable monotherapy with clozapine or olanzapine increases the incidence of diabetes mellitus in people with schizophrenia.

Risk factors: Participants diagnosed with diabetes mellitus or hospitalised with diabetic ketoacidosis were identified from the Department of Veterans Affairs and were predominantly older and male. Time to diagnosis and hospitalisation was modelled using the Cox proportional hazards models. Attributable risks of each outcome associated with different antipsychotics were calculated. The five ant...

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Metabolic syndrome in schizophrenia - who is more to blame: FGA polypharmacy or clozapine monotherapy?

BACKGROUND To establish the prevalence of metabolic syndrome and its parameters in group of patients with schizophrenia in polypharmacy - receiving first generation antipsychotics versus clozapine alone treated group. SUBJECTS AND METHODS 48 outpatients with schizophrenia divided into two groups: the first group of 21 patients in polypharmacy with first generation antipsychotics, and the seco...

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ژورنال

عنوان ژورنال: British Journal of Psychiatry

سال: 1997

ISSN: 0007-1250,1472-1465

DOI: 10.1192/bjp.171.1.90c